Research Impact

Research funded by Lipedema Foundation is being published and presented. Although sample sizes remain small for now, the results of these early studies help to inform future priorities and research impact.

ENROLLING studies & ClinicaL Trials

Patient Registry now open at <— DO THIS NOW :-)

25cohort collaboration

INSIGHT at the University of Arizona and Clinical Trials Info

Vanderbilt INFORM Survey

Vanderbilt Treatment Study for Lipedema

UTHouston NIRFLI imaging Clinical Trial

Live patient research during FDRS 2019 conference Apr 10 - 12, 2019 (closed)

Australia team

Research during FDRS 2018 conference (closed)

Research during FDRS 2017 conference, GAIT (closed)

Quadrivas I and Quadrivas II (closed)

Progress Toward Diagnostic tests

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema.


INSIGHT at The University of Arizona



Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue

Hypertrophic adipocytes, increased numbers of macrophages and blood vessels, and dilation of capillaries in thigh tissue of non-obese women with lipedema suggest inflammation, and angiogenesis occurs independent of obesity and demonstrates a role of altered vasculature in the manifestation of the disease.

Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

This article describes the impact of the paper: Mobilizing the lymphatic system may help combat obesity-induced metabolic syndrome

Lipedema: Friend and Foe

"In new data collected, lipedema was associated with a low risk of diabetes (2%), dyslipidemia (11.7%) and hypertension (13%) despite an obese average body mass index (BMI) of 35.3 ± 1.7 kg/m2."

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema.

"CONCLUSIONS: Internal metrics of tissue sodium and adipose content are elevated in patients with lipedema, potentially providing objective imaging-based biomarkers for differentially diagnosing the under-recognized condition of lipedema from obesity."

Adipose stem cells from lipedema and control adipose tissue respond differently to adipogenic stimulation in vitro.

“Lipedema adipose cells not only differ in their lipid storage capacity but also in their adipokine expression pattern.“

Differentiating lipedema and Dercum's disease

"CONCLUSIONS: The significantly lower prevalence of DM2 in people with lipedema compared with DD may be due to the greater amount of gynoid fat known to be protective against metabolic disorders. The high percentage of hypermobility in lipedema patients indicates that it may be a comorbid condition. The location of fat, high average daily pain, presence of lipomas and comorbid painful disorders in DD patients may help differentiate from lipedema."

Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema

Low dose d-amphetamine induced regression of liver fat deposits in Dercum disease

Subcutaneous adipose tissue therapy reduces fat by dual X-ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease


Conferences and Presentations

Lipedema Sandbox - GRC Lymphatics 2018

Lipedema Sandbox - GRC Lymphatics 2018

Erik Lontok, PhD, Lipedema Foundation

The Lipedema Sandbox; Gordon Research Lymphatics Conference Poster - March 2018

Frontiers of Lipedema Research; FDRS 2018 - April 2018

Lipedema Australia - August 2018

Karen Herbst and the University of Arizona TREAT Program Team

Fat Disorders Research Society #FDRS2018 - April 2018

Obesity Medicine Association Meeting Lipedema Diagnosis and Treatment – September 2017

Asia Pacific Lymphology Conference: New Networks New Solutions, May 2016

  • Lipedema, Assessment, Diagnosis and Treatment – 3 hour workshop

  • SAT Disorders Similarities and Differences

  • Lipedema Is Not Just Fat Legs

  • Lymphatic Dysfunction in Obesity and Diabetes

  • All About Lipedema and Treatment

Fat Disorders Research Society #FDRS2017 – April 2017

  • Keynote Address: Dercum’s disease vs. Lipedema

  • Quadrivas Therapy

  • Dercum's Disease Research

Vanderbilt team

MRI Tools to Diagnose and Evaluate Mechanisms of Lipedema; Fat Disorders Research Society - April 2018 (Rachelle Crescenzi)

Lymphatic imaging in patients with lipedema and lymphedema: potential applications to CNS lymphatics; Johns Hopkins University - February 2018 (Manus Donahue)

Lymphatic vessel visualization using a novel, non-invasive MR lymphangiography technique; Association of Academic Physiatrists -February 2018 (Paula Donahue)

Lymphedema and lipedema in women: insights into lymphatic disease; Vanderbilt University Institute of Imaging Science - January 2018 (Rachelle Crescenzi)

A novel application of quantitative sodium MRI for distinguishing lipedema from obesity; Vanderbilt Univ. Institute of Imaging Science Annual retreat – June 2017 (Rachelle Crescenzi)

Lymphedema and Lipedema in Women: Emerging Mechanistic Insights; Society for Vascular Medicine 28th Annual Scientific Sessions – June 2017 (Rachelle Crescenzi)

A novel application of quantitative sodium MRI for distinguishing lipedema from obesity; X-Nuclei Imaging Study Group of International Society for Magnetic Resonance in Medicine (ISMRM) 25th annual meeting - April 2017 (Rachelle Crescenzi)

Magnetic resonance imaging reveals high tissue sodium and fat in women with lipedema; Fat Disorders Research Society - April 2017 (Rachelle Crescenzi)

Functional Imaging of Sodium and Lymphatics in Patients with Lipedema; Lipedema Scientific Retreat - October 2016 (Rachelle Crescenzi)

St George's University of London Team

Lipedema: a genetic condition?; Klose Lymphedema Conference Denver – May 2017 (Kristiana Gordon)

Exploring different oedemas; Living with Lymphoedema Conference London, Royal Marsden Hospital – September 2017 (Kristiana Gordon)

Lipedema: An Inherited Condition; Lipoedema UK Conference – October 2017 (Pia Ostergaard and Prof. Peter Mortimer)

Australian Team

Lipedema Australia National Conference - August 2018 (Neil Piller)

Yann Klimentidis

Genetic factors underlying the lipedema phenotype; Fat Disorders Research Society — April 2018

Joe Rutkowski and Adri Chakraborty

Data presented; Keystone Symposium “Vascular Biology and Human Diseases: From Molecular Pathways to Novel Therapeutics” — February 2018

Data presented; 2018 Gulf Coast Vascular Research Consortium meeting— March 2018

Data presented; Experimental Biology — 2018

Carrie Shawber

Notch4 Mutant Mice Develop a Lipedema-Like Syndrome Associated with Dermal Lymphatic Defects; Lymphatics Gordon Research Conference – March 2018

Role of Notch and lymphatic dysfunction in lipedema; NAVBO Vascular Biology - October 2018

Rene Haegerling

VIPAR - a light sheet imaging based approach to quantitative 3D histopathology applied to human tissue; COMPARE light-sheet imaging Workshop, University of Birmingham, UK — February 2018

VIPAR – a new potential diagnostic tool to investigate lipoedema and lymphedema in human patients; Annual meeting of the German Society for Lymphology, Germany — October 2018

Echoe Bouta

Comparison of lymphatic function techniques; Lymphatic Forum Chicago – June 2016

Javier Jaldin-Fincati

Communication between adipose and lymphatic microvascular endothelial cells; World Congress of Lymphology – September 2017


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